L-argininato copper(II) complexes in solution exert significant selective anticancer and antimicrobial activities

A search for new drugs that overcome the multidrug resistance of microorganisms or are effective against cancer cells prompted us to investigate the binary and ternary Cu(II) complexes containing L-arginine, [CuCl(L-Arg)(phen)]Cl·2H₂O (phen = 1,10-phenanthroline) ( 1 ) and [Cu(L-Arg)₂(H₂O)]C₂O₄·6H₂O ( 2 ), for which crystal and molecular structures were characterized previously. In order to discuss the biological function, the complexes have been screened for their antitumor activity against A549 (human lung cancer cells), HepG2 (human liver hepatocellular carcinoma cells) and antimicrobial activity. To identify the complexes forms existing in the solutions of 1 and 2 crystals, the results obtained from EPR, NIR–Vis–UV and MS (mass spectrometry) measurements were correlated with those from analysis of potentiometric titration of Cu(II)―L-Arg and Cu(II)―L-Arg―phen systems. This comprehensive study indicated that the [Cu(L-Arg)(phen)]²⁺ and [Cu(L-Arg)₂]²⁺ species are dominant in the solution. Complexes 1 and 2 were found to present specific ligand-dependent cytotoxic and antiproliferative potential against cancer cells. They also show antibacterial activity against Gram-positive and Gram-negative bacteria as well as display antifungal properties.     

含氟CaO-P2O5-SiO2-Na2O-B2O3玻璃陶瓷的制备及性能表征

采用溶胶-凝胶法制备CaO-P₂O₅-SiO₂-Na₂O-B₂O₃体系前驱体粉末,用CaF₂替代部分CaO再次制备前驱体粉末。 通过TG-DSC分析确定结晶温度为865 ℃,经过热处理获得主晶相为Na₆Ca₃Si₆O₁₈的玻璃陶瓷。 通过X射线衍射(XRD)、傅里叶红外光谱(FTIR)、扫描电子显微镜(SEM)等技术手段及体外生物活性实验分析玻璃陶瓷的显微结构及性能。 结果表明,CaF₂的加入能提高玻璃陶瓷的体积密度、抗折强度和弹性模量,并且不会破坏玻璃陶瓷的生物活性。     

Cu催化吲哚啉的炔丙基烷基化/脱氢对映选择性合成手性N-炔丙基吲哚化合物(英文)

基于吲哚啉的Cu催化不对称炔丙基烷基化及DDQ脱氢策略,成功合成了手性N-炔丙基吲哚化合物.通过使用一个结构刚性的酮亚胺三齿P,N,N-配体,反应获得了很好的对映选择性.该方法反应条件温和、底物适用范围广、产物收率高、立体选择性好,为手性N-炔丙基吲哚化合物的合成提供了一条简捷、高效的新途径.     

岩石爆破破碎时间及微差起爆延时优化

利用分形理论分析岩石爆破的破碎时间，提出了岩石爆破破碎时间的计算方法和微差起爆延时优化的一种途径。     

计算机模拟升降法试验的研究

介绍了计算机模拟感度试验的原理，运用计算机模拟方法研究了升降法试验的初始参数选择对感度分布参数估计精度的影响，取得了对升降法有利的试验条件。     

爆炸应力波作用下裂纹与孔洞的动态焦散线分析

将高速摄影技术与动态焦散线方法相结合，研究了爆炸应力波对裂纹、空孔的作用历史，记录了环绕它们的动态焦散斑图，给出了爆炸应力场中裂纹尖端复合应力强度因子的时间依赖关系以及空孔周围应力场分布的瞬态变化过程，为固体介质的爆破机理研究提供了新方法。     

Higher alcohol synthesis over Cu-Fe composite oxides with high selectivity to C2+OH

Cu-Fe composite oxides were prepared by co-precipitation method and tested for higher alcohol synthesis from syngas. The selectivity to C2+OH and C6+OH in alcohol distribution was very high while the methane product fraction in hydrocarbon distribution was rather low, demonstrating a promising potential in higher alcohols synthesis from syngas. The distribution of alcohols and hydrocarbons approximately obeyed Anderson-Schulz-Flory distribution with similar chain growth probability, indicating alcohols and hydrocarbons derived from the same intermediates. The effects of Cu/Fe molar ratio, reaction temperature and gas hourly space velocity (GHSV) on catalytic performance were studied in detail. The sample with a Cu/Fe molar ratio of 10/1 exhibited the best catalytic performance. Higher reaction temperature accelerated water-gas-shift reaction and led to lower total alcohols selectivity. GHSV showed great effect on catalytic performance and higher GHSV increased the total alcohol selectivity, indicating there existed visible dehydration reaction of alcohol into hydrocarbon.     

Enamines of 1,3-dimethylbarbiturates and their symmetrical palladium(II) complexes: synthesis,characterization and biological activity

Transition Metal Chemistry - Three 1,3-dimethylbarbiturate-enamine derivatives and their symmetrical palladium(II) complexes were prepared and characterized by spectroscopic methods. In addition,...